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Blog #16:Chronic inflammation (CI)- “Enemy #1” (Part 3: A multisystem pathology)
Other than my ad nauseum repetition of “CI being the basis of all diseases,” our discussions up to this point regarding CI have really...

Blog #17: Neuroimmunology
Contrary to previous beliefs, the brain is not an “immune-privileged” organ. The nervous system and the immune system share an intimate...


Blog #18:Autoimmune disease (Part 1) - Etiologies
When, for some unknown reason, the body incorrectly identifies itself (i.e., self) as foreign (i.e., non-self), effectively, the body...

Blog #19: Autoimmune disease (Part 2)- Female bias)
The prevalence of autoimmune diseases in females is an area of intense research and speculation as to its etiologies. This blog will...


Blog #20: Autoimmune disease (Part 3)- Clinical considerations)
When discussing autoimmune diseases in the previous blog (#19), we identified the phenomenon of epitope spreading contributing to the...

Blog #21: Immunotherapeutics (Monoclonal antibodies, biosilimars biologics and small molecule drugs)
Among all the topics discussed in these blogs, the next three (immunotherapies, cancers, and infectious diseases) will probably be out of...

Blog #22: Immunotherapeutic procedures (PART 1: Stem cell transplantation therapy)
A rapidly increasing area of immunotherapy is the role of immunogenomic cellular and genetic editing and replacement procedures and cell...

Blog #23: Immunotherapeutic procedures (Part 2: Homograph transplantation)
A branch of immunotherapies of profound importance is that of organ, tissue, and cell transplantation. So too are the profound...

Blog #24: Immunotherapeutic procedures (Part 3: Genetic engineering/ modifications)
The use of the word “cure” in medicine always needs delicate consideration. If you recall, the only times I have used the word in earlier...

Blog #25: Immunotherapeutic procedures (Part 4: CAR-T & CAAR-T cell therapy)
Chimeric antigen receptor T cells (CAR-T cells) are T cells that have been genetically engineered to give them the new ability to target...

Blog #26: Immunotherapeutic procedures (Part 5: CRISPR-Cas9 therapy)
One of the effective ways of treating autoimmune disease is to identify the “signature” of offending genes (their “gene expression” or...


Blog #27: Cancer (Part 1)- Epidemiology
You have probably seen this popular sign by now with a red slash through the word "Cancer": You’ve just gotta love it. I doubt there are...

Blog #28: Cancer (Part 2) - Etiologies
Inherited genetic disorders result in gene alterations in virtually every cell in our body. As a result, these disorders tend to affect...

Blog #29: Cancer (Part 3)- Microbiome, XCI, and microRNA
As mentioned in our discussion of infectious agents (in our last Blog #28), it is estimated that individual microbial pathogens...


Blog #30: Cancer (Part 4) -Clinical considerations & diagnosis
The pathological path for cancers is the abnormal proliferation of cells different in type, numbers, and actions of otherwise normal...

Blog #31: Cancer treatment (Part 1)- Chemotherapy, Radiation & Molecular targeted therapy
Combination strategies using immunotherapies and genetic procedures in conjunction with chemotherapies, radiation therapies, and surgery...

Blog #32: Cancer treatment (Part 2)-Immunotherapeutics, Cellular & Genetic procedures
In a discussion on immunotherapies in the treatment of cancers, the most appropriate place to begin is with the monoclonal antibodies....

Blog #33: Cancer treatment (Part 3)- Idiotype-anti-idiotype Regulatory Circuit or Loop
Way back in Blog #9, we referenced the Idiotype-anti-idiotype Regulatory Circuit (or Loop) and postponed its full discussion because of...

Blog #34: Cancer treatment (Part 4)- Combination strategies in cancer immunotherapy
Back in Blog #9, I promised to return to this (yet another) complex topic, but I also promised to be brief. So, once again, let me take a...

Blog #35: Immunology’s role in infectious disease (Part 1: Pathogenesis)
Most microorganisms are based on a DNA genome. Some viruses, including the coronavirus, have RNA-based genomes instead. In general, viral...
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